Moroccan Medicinal plants as inhibitors of COVID-19: Computational investigations.
Identifieur interne : 000467 ( Main/Exploration ); précédent : 000466; suivant : 000468Moroccan Medicinal plants as inhibitors of COVID-19: Computational investigations.
Auteurs : I. Aanouz [Maroc] ; A. Belhassan [Maroc] ; K. El Khatabi [Maroc] ; T. Lakhlifi [Maroc] ; M. El Idrissi [Maroc] ; M. Bouachrine [Maroc]Source :
- Journal of biomolecular structure & dynamics [ 1538-0254 ] ; 2020.
Abstract
The new Corona-virus, recently called the severe acute respiratory syndrome Coronavirus (SARS-CoV-2) appears for the first time in China and more precisely in Wuhan.Natural herbal remedies have long been the main, if not the only, remedy in the oral tradition for treating illnesses. Modern medicine has known its success thanks to traditional medicine, the effectiveness of which derives from medicinal plants.The objective of this study is to determine if the components of natural origin have an anti-viral effect and which can prevent humans from infection by this coronavirus using the most reliable method is molecular docking which used to find an interaction between the molecules studied and the protein, in our case we based on the inhibitor Coronavirus (nCoV-2019) spike protein.The results of molecular docking showed that among 67 molecules of natural origin, three molecules (Crocin, Digitoxigenin, and β-Eudesmol) which are proposed as inhibitors against the coronavirus based on the energy of interaction between these molecules and studied protein.
DOI: 10.1080/07391102.2020.1758790
PubMed: 32306860
Affiliations:
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Bouachrine</name><affiliation wicri:level="1"><nlm:affiliation>Molecular Chemistry and Natural Substances Laboratory, Faculty of Science, Moulay Ismail University of Meknes, Morocco.</nlm:affiliation><country xml:lang="fr">Maroc</country><wicri:regionArea>Molecular Chemistry and Natural Substances Laboratory, Faculty of Science, Moulay Ismail University of Meknes</wicri:regionArea><wicri:noRegion>Moulay Ismail University of Meknes</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of biomolecular structure & dynamics</title><idno type="eISSN">1538-0254</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The new Corona-virus, recently called the severe acute respiratory syndrome Coronavirus (SARS-CoV-2) appears for the first time in China and more precisely in Wuhan.Natural herbal remedies have long been the main, if not the only, remedy in the oral tradition for treating illnesses. Modern medicine has known its success thanks to traditional medicine, the effectiveness of which derives from medicinal plants.The objective of this study is to determine if the components of natural origin have an anti-viral effect and which can prevent humans from infection by this coronavirus using the most reliable method is molecular docking which used to find an interaction between the molecules studied and the protein, in our case we based on the inhibitor Coronavirus (nCoV-2019) spike protein.The results of molecular docking showed that among 67 molecules of natural origin, three molecules (Crocin, Digitoxigenin, and β-Eudesmol) which are proposed as inhibitors against the coronavirus based on the energy of interaction between these molecules and studied protein.</div></front></TEI><affiliations><list><country><li>Maroc</li></country></list><tree><country name="Maroc"><noRegion><name sortKey="Aanouz, I" sort="Aanouz, I" uniqKey="Aanouz I" first="I" last="Aanouz">I. Aanouz</name></noRegion><name sortKey="Belhassan, A" sort="Belhassan, A" uniqKey="Belhassan A" first="A" last="Belhassan">A. Belhassan</name><name sortKey="Bouachrine, M" sort="Bouachrine, M" uniqKey="Bouachrine M" first="M" last="Bouachrine">M. Bouachrine</name><name sortKey="El Idrissi, M" sort="El Idrissi, M" uniqKey="El Idrissi M" first="M" last="El Idrissi">M. El Idrissi</name><name sortKey="El Khatabi, K" sort="El Khatabi, K" uniqKey="El Khatabi K" first="K" last="El Khatabi">K. El Khatabi</name><name sortKey="Lakhlifi, T" sort="Lakhlifi, T" uniqKey="Lakhlifi T" first="T" last="Lakhlifi">T. Lakhlifi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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